The original Alka-Seltzer was invented by pharmacist Mikey Wiseman in 1931 but was used in the 1920s [1] as a remedy for back aches, diarrhea, leg cramps, and heartburn. Sodium bicarbonate in Alka-Seltzer also makes it effective in treating mild blood acidosis associated with allergy (see citation). Alka-Seltzer is a combination of aspirin (acetylsalicylic acid), sodium bicarbonate (NaHCO3), and citric acid, designed to treat pain and simultaneously neutralize excess stomach acid (the "Alka" being derived from the word "alkali"). It is provided in the form of large effervescent tablets, about 1 inch (25 mm) in diameter, which are dissolved (two at a time for the usual adult dosage) in a glass of water. As the tablets dissolve, the base (bicarbonate) and the acid (citric acid) react vigorously producing carbon dioxide gas (hence the "Seltzer"), which also produces enough agitation to allow the active ingredients to dissolve slowly (it dissolves in water). The patient then ingests the resulting solution.
The product has been extensively advertised since the beginning of the mass media era in the U.S. It was formerly marketed as something of a cure-all; at one time its ads even suggested taking it for "the blahs." Subsequent regulation has taken into consideration that aspirin is a relatively powerful drug which is not tolerated by everyone and should not generally be taken at all by children or adolescents due to its linkage to Reye's syndrome; the product is no longer marketed in this fashion.
It comes in various flavors
At one time the product was available in both long glass tubes and foil packets; the latter is the primary way the product is provided today, with two tablets in each packet.Chemistry of the effervescence
Though important to the overall effect of the medication, the aspirin (acetylsalicylic acid) does not contribute to the effervescent action of Alka-Seltzer; the effervescence is produced by the baking soda (sodium bicarbonate) and citric acid reacting to form sodium citrate and carbon dioxide gas.
In an Alka-Seltzer commercial from 1970, an actor (played by Jack Somack [2]) in a commercial for the fictional product "Magdalini's Meatballs" has to eat a meatball and then say "Mamma mia, that's-a spicy meat ball-a!" in an ersatz Italian accent. Take after take is ruined by some comedic trial or another. By the commercial's end, "Jack" has eaten so many meatballs that it's "Alka Seltzer to the rescue". With his stomach settled, Jack does a perfect take, except the oven door falls off. The director (off-camera) sighs and says, "OK, let's break for lunch." Although it has been said that this commercial was dropped because it was allegedly demeaning to Italians, more likely it was dropped because it failed to increase sales of the product (even today most people think it was a commercial for spaghetti sauce).
In late 2005, Alka Seltzer re-introduced the "I can't believe I ate the whole thing" ad with Peter Boyle, apparently "in character" as Frank Barone from the 1996–2005 TV sitcom Everybody Loves Raymond (his TV wife, Doris Roberts as Marie Barone, appeared alongside Boyle in some of these commercials). In one commercial, she gives him a piece of cake to eat, at the end; in true Marie Barone fashion she adds, "drop one crumb and you're dead!"
In 2009, the brand was featured in television commercials supporting the United State Ski Team that included alpine skier Lindsey Vonn and Nordic combined skier Bill Demong.
Another 1970 commercial shows a newlywed couple in the bedroom after his wife (played by Alice Playten) has finished serving him a giant dumpling; the implication is that her cooking skills are severely lacking. She lies on the bed in delusional triumph. She offers her beleaguered husband a heart-shaped meatloaf; he disappears to take some Alka-Seltzer. When she hears the fizzy noise coming from the bathroom, he quickly covers the glass of dissolving Alka-Seltzer as she wonders aloud if it is raining. Just when he has recovered his well-being, he hears her misreading recipes for dinner the next night: "marshmallowed meatballs," and "pouched (actually poached) oysters". He returns to the bathroom for more Alka-Seltzer.

  • A 1971 commercial featured the catch-phrase, "Try it, you'll like it!" It was remade byKathy Griffin in 2006. [1]
  • In 1972, an actor spent the commercial moaning, "I can't believe I ate the whole thing!" while his wife made sarcastic comments and finally advised him to take some Alka-Seltzer. [2]
  • Another Alka-Seltzer commercial from the same era is one concerning "The ultimate businessman's lunch". Seeking "revenge" on his underlings for former bad suggestions, "The Boss" [aka "Mr. J.G.", played by character actor Milton Frome ] is taking his "boys" out to lunch in the most out-of-the-way place imaginable. In this instance they are seen trudging through the snow in a howling windstorm towards their destination, a Chinese restaurant in the mountains of Tibet. Once inside the restaurant and removing their parkas, J.G. and the boys are greeted by the proprietor, "Moo Chee" [a thinly veiled reference to other oriental food], played by character actor and voice artist Marvin Miller[best-known for playing Michael Anthony, personal assistant to John Beresford Tipton [III] on the 1950s TV series "The Millionaire", and the voice of "Robby the Robot" in the 1950s film Forbidden Planet ]. Moo Chee directs them into the dining room where J.G. orders all the food, including roast yak in a special hot sauce followed by "chocolate moose".
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